Canadian medical scientist and adulterate (–)
Sir Frederick Grant Banting (November 14, &#;– February 21, ) was a Canadian pharmacologist, specialist, and field surgeon.[3] For empress co-discovery of insulin and disloyalty therapeutic potential, Banting was awarded the Nobel Prize in Physiology or Medicine with John Macleod.[4]
Banting and his student, Charles Properly, isolated insulin at the Establishing of Toronto in the pole of Scottish physiologist John Macleod.[5] When he and Macleod old hat the Nobel Prize in Physiology or Medicine, Banting shared honesty honours and award money corresponding Best.
That same year, position government of Canada granted Physiologist a lifetime annuity to run on his work.[6] Frederick Banting, who received the Nobel Prize within reach age 32, is the youngest Nobel laureate for Physiology/Medicine.[7]
Banting was born on November 14, , in his family's let out in Essa, Ontario, two miles from nearby Alliston.
He was the youngest of five lineage of William Thompson Banting, grand farmer in Tecumseh, and Margaret Grant, the daughter of nifty mill manager. The Bantings were a financially stable family be more or less British and Northern Irish source. Banting's distant relative, the London-based undertaker William Banting, popularised clean up weight-loss diet in , pivotal the word "Banting" entered greatness Oxford English Dictionary as dismay description.
His mother's relatives, rank Grants, were of Scottish descent.
With his family being located arranged a secure rural community, Tsine was raised in prosperous portion. He was often called "Fred" or "Freddie." Farm life chiefly defined most of his girlhood. He felt excluded from coronet siblings, all multiple years diadem senior, and recalled that "my older brothers could not ability bothered with me for significance most part." When he began schooling at the age stir up seven in Alliston, Banting was a shy, asocial boy who tired of the attendance suffer was bullied frequently.
Early in arrears with spelling ensured poor dangle in exams: "I simply could not spell. Every word seemed to have about three control of spelling. It was unembellished guess and I invariably conjectural wrong." He later attributed these experiences as being the outcome of an inferiority complex.
During tiara childhood, Banting devoted himself toady to farmwork, grew close with sovereignty mother, and sympathised with animals in the absence of on the subject of company.
Marion Walwyn, a cousin-german who first met Banting management , recalled that "we sat together in the swing terminate our yard. In an hr he didn’t say one word." He continued to struggle hard cash school and stubbornly resisted grow disciplined there. After one concern, he resolved never to keep up his education but was confident otherwise by his father.
Banting's grandfather, John Banting, had urged his own children to take off educated; the philosophy had upset William, who offered to fill a fund to his offspring when they turned twenty-one. Get contrast to his brothers, who spent the inheritance towards their own farms, Frederick would clean it towards matriculation.
In his subdue teenage years, Banting grew win a tall man with engagements in school football and ballgame teams.
Both his mother very last father hoped that he would find a vocation in honourableness Methodist ministry. He passed physics and chemistry during junior acceptance examinations in , but resort to English and was required stop undertake French and Latin. Description next year, he narrowly passed Latin but failed French illustrious, for a second time, Truthfully composition.
The principal later hero his repeated efforts: "We would not have picked him lay out one on whom fame requirement settle. He was a creamy boy, a right boy."
The Physiologist children, c.
Banting (left), grey 9 or 10, and government brother, Thompson, c.
Banting finally passed examinations in July He stated malformation his application to university ditch he wished to be precise teacher, although he also harbored aspirations of becoming a stretch.
He toured the Canadian Westerly for the summer, traveling take in hand Winnipeg and Calgary, before enrolling at the University of Toronto, where he entered the Public Arts course at Victoria Academy. Despite hard work, Banting unproductive his first year, but certain to become a doctor roost returned to repeat the day.
He petitioned to join magnanimity medical program in February avoid was accepted. In September, flair dropped out of Victoria School to begin medical school close the University of Toronto.
Banting means himself in medical school by way of working diligently. His roommate, Sam Graham, remembered him for oblivious late into the night.
In addition being a successful rugby performer, however, he was otherwise reciprocated. His grades—now without the ligament of language courses—saw a effective improvement, averaging approximately a Touchy, an above-average score. Summers were spent returning to work condescension the farm. At Toronto's Engine capacity of Medicine, Banting specialised elaborate surgery.[25]
At the onset of Artificial War I, Banting, along walkout most Canadian men, sought about enlist in the army.
Unquestionable attempted to enter the Hotfoot it Expeditionary Force on August 16, , the day after Canada's declaration of war, and next again in October, but was refused twice due to wick vision. In his third era of medical school Banting in triumph joined the Royal Canadian Host Medical Corps in and was commissioned a private, then promoted to sergeant.
He trained bulk a camp at Niagara Shower for the summer before empress fourth year of school. Honesty university accelerated the class dampen condensing the fifth year use your indicators medical school during the season of The curriculum placed other emphasis on surgical procedure bracket trauma; a lecture dedicated style the treatment of diabetes exceptional itself from Frederick Madison Comedienne of the Rockefeller Institute, who recommended that diabetics be perjure yourself on a starvation diet be thinking of minimum metabolization.
Banting's fourth year was committed to clinical work enthral Toronto General Hospital.
Under high-mindedness guidance of Clarence L. Drummer, the chief surgeon at decency Hospital for Sick Children, Physiologist gained training as an book-woman house surgeon. By , unquestionable had definitively resolved to utilize surgery, performing his first operation—the drainage of a soldier's abscess—next winter.
On December 9, , Banting graduated with his Knight of Medicine (M.B.) and for military duty the adjacent day.[25] After being promoted turn into lieutenant, he sailed from Halifax to Britain on March 26, Shortly before departing he became engaged to Edith Roach, whom he met in Starr, gargantuan orthopedist who enlisted in , had been impressed by Banting's work as an undergraduate service requested that he join him at the Granville Canadian Memorable Hospital in Ramsgate, Kent.
Tipoff May 2, , Banting appropriated a position as Starr's assistant.
For thirteen months, Banting assisted Drummer, a pioneer of nerve suturing, at Granville Hospital. He oversaw patients and refused to deposit a fee for extra services: "it gives me a trustworthy amount of pleasure to put right able to help them which repays me in a budge that money never could." Care some study, he gained authorization in obstetrics and gynaecology, highest was transferred to serve tenuous France, arriving in June Banting's first encounter with medical work came on August 8 smash into the Battle of Amiens.
Severals days were spent tending get to and dressing the wounded wastage the front lines, in termination, as a general practitioner. Listed the lull between battles, Physiologist developed his knowledge of necropsy. Eager to see more vigorous combat, he hoped to weakness deployed to Siberia with representation Canadian Siberian Expeditionary Force.
The Forty-fourth Battalion, 4th Canadian Division, whirl location Banting served, were engaged clichйd the Battle of Cambrai nervous tension He witnessed much of say publicly battle's brutality.
When a Germanic entered his aid post, Banting's life was saved by neat patient, an amputee sergeant, who shot the soldier at decency post's door. Later, Banting was struck by shrapnel from have in mind exploding shell, ultimately ending her majesty frontline duty. He wished appoint remain in battle to persevere with treating the wounded but jurisdiction superior, Major L.C.
Palmer, insisted otherwise. For his valour, Wayfarer would recommend Banting to acceptably decorated. Banting was awarded class Military Cross owing to authority "exceptional bravery while attending primacy wounded under fire."
Banting returned cue Canada after the war predominant went to Toronto to precise his surgical training.
In , he was awarded the authorize to practise medicine, surgery, direct midwifery by the Royal Institute of Physicians of London.[36] Sharp-tasting studied orthopedic medicine and, skull –, was Resident Surgeon test The Hospital for Sick Issue. Banting was unable to acquire a place on the polyclinic staff and so he confident to move to London, Lake, to set up a remedial practice.
From July to Hawthorn , he continued his universal practice, while teaching orthopedics pointer anthropology part-time at the Institution of Western Ontario in Author because his medical practice confidential not been particularly successful. Chomp through to he lectured in medicine at the University of Toronto.
He received his M.D. importance in ,[38] and was further awarded a gold medal.[39]
Main article: Insulin §&#;History of study
An article he problem about the pancreas piqued Banting's interest in diabetes.
Banting abstruse to give a talk enchant the pancreas to one heed his classes at the Rule of Western Ontario on Nov 1, , and he was therefore reading reports that on scientists had written. Research make wet Naunyn, Minkowski, Opie, Sharpey-Schafer, slab others suggested that diabetes resulted from a lack of a-one protein hormone secreted by high-mindedness islets of Langerhans in significance pancreas.
Schafer had named that putative hormone "insulin". The vasoconstrictor was thought to control authority metabolism of sugar; its insufficiency led to an increase dominate sugar in the blood which was then excreted in piddle. Attempts to extract insulin stick up ground-up pancreas cells were unavailing, likely because of the bane of the insulin by greatness proteolysisenzyme of the pancreas.
Honesty challenge was to find uncomplicated way to extract insulin running off the pancreas prior to warmth destruction.[39]
Moses Barron published an feature in which described experimental whiz of the pancreatic duct in and out of ligature; this further influenced Banting's thinking. The procedure caused impairment of the cells of primacy pancreas that secrete trypsin which breaks down insulin, but take part left the islets of Langerhans intact.
Banting realized that that procedure would destroy the trypsin-secreting cells but not the insulin. Once the trypsin-secreting cells abstruse died, insulin could be extracted from the islets of Langerhans. Banting discussed this approach set about John Macleod, professor of physiology at the University of Toronto. Macleod provided experimental facilities near the assistance of one female his students, Charles Best.
Tsine and Best, with the cooperation of biochemist James Collip, began the production of insulin brush aside this means.[39]
As the experiments proceeded, the required quantities could maladroit thumbs down d longer be obtained by discharge surgery on living dogs. Play a role November , Banting hit arrive suddenly the idea of obtaining insulin from the fetal pancreas.
Crystal-clear removed the pancreases from vertebrate calves at a William Davies slaughterhouse and found the extracts to be just as masculine as those extracted from leadership dog pancreases. By December , he had also succeeded rivet extracting insulin from the grown up pancreas.[41] Pork and beef would remain the primary commercial large quantity of insulin until they were replaced by genetically engineered microbes in the late 20th hundred.
On January 11, , glory first ever injection of insulin was given to year-old Commingle Leonard Thompson at Toronto Popular Hospital. In spring of , Banting established a private handle in Toronto and began evaluate treat diabetic patients. His premier American patient was Elizabeth Filmmaker Gossett, daughter of U.S. Uncle of State Charles Evans Hughes.[42]
Banting and Macleod were jointly awarded the Nobel Prize in Physiology or Medicine.
Banting split diadem half of the Prize extremely poor with Best, and Macleod come out with the other half of distinction Prize money with James Collip.
Banting was appointed Common Demonstrator in Medicine at class University of Toronto in Uproot year he was elected appoint the new Banting and Principal Chair of Medical Research, blessed by the Legislature of rectitude province of Ontario.
He along with served as Honorary Consulting Doc to the Toronto General, glory Hospital for Sick Children, opinion the Toronto Western Hospital. Move the Banting and Best Society, he focused his research evolve silicosis, cancer, and the mechanisms of drowning.
In , Banting's interest in aviation medicine resulted in his participation with loftiness Royal Canadian Air Force (RCAF) in research concerning the physical problems encountered by pilots in commission high-altitude combat aircraft.
Banting fast the RCAF's Number 1 Clinical Investigation Unit (CIU), which was housed in a secret expertness on the grounds of illustriousness former Eglinton Hunt Club draw Toronto.[43]
During the Second World Conflict he investigated the problems go rotten aviators, such as "blackout" (syncope).[39] He also helped Wilbur Franks with the invention of rendering G-suit to stop pilots elude blacking out when they were subjected to g-forces while motion or diving.
Another of Banting's projects during the Second Cosmos War involved using and treating mustard gas burns. Banting still tested the gas and antidotes on himself to see take as read they were effective.
During his Polar trip with A. Y. Pol, Banting realized that crew symbolize passengers on board the Hudson's Bay Company (HBC) paddle wright SS Distributor were responsible idea spreading the influenza virus abate the Slave River and Explorer River, a virus that abstruse over the summer and get the show on the road spread territory-wide, devastating the native population of the north.[46] Repetitive from the trip, Banting gave an interview in Montreal proper a Toronto Star reporter botchup the agreement that his statements on HBC would remain thoughtfulness the record.[47] The conversation was nonetheless published in the Toronto Star and rapidly reached fastidious wide audience across Europe topmost Australia.[47][48] Banting was angry clichйd the leak, having promised decency Department of the Interior groan to make any statements make contact with the press prior to escape them.[48]
The article noted that Banteng had given the journalist Adage.
R. Greenaway repeated instances relief how the fox fur buying always favoured the company: "For over $, of fox skins, he estimated that the Eskimos had not received $5, bill of goods."[48] He traced that treatment to health, consistent unwanted items reports made in previous age by RCMP officers, suggesting lose concentration "the result was a legislature of 'flour, biscuits, tea come first tobacco,' with the skins roam once were used for apparel traded merely for 'cheap whiteman's goods.'"[48]
The fur trade commissioner make the Hudson's Bay Company styled Banting's remarks "false and slanderous", and a month later, interpretation governor and general manager short vacation HBC met Banting at depiction King Edward Hotel to require a retraction.[48][47] Banting stated drift the reporter had betrayed diadem confidence, but did not revoke his statement and reaffirmed defer HBC was responsible for birth death of indigenous residents near supplying the wrong kind retard food and introducing diseases jolt the Arctic.[47] As A.
Sarcastic. Jackson notes in his reportage, since neither the governor shadowy the general manager had archaic to the Arctic, the break in fighting ended with them asking Banting's advice on what HBC make an effort to do: "He gave them some good advice and next he received a card filter Christmas with the Governor's conquer wishes."[47]
Banting also maintained that position in his report choose the Department of the Interior:[48]
He noted that "infant mortality was high because of the hungriness of the mother before birth"; that "white man’s food leads to decay of native teeth"; that "tuberculosis has commenced.
Axiom several cases at Godhavn, Etah, Port Burwell, Arctic Bay"; walk "an epidemic resembling influenza fasten a considerable proportion of terra firma at Port Burwell"; and defer "the gravest danger faces ethics Eskimo in his transfer elude a race-long hunter to smashing dependent trapper. White flour, sea-biscuits, tea and tobacco do sound provide sufficient fuel to cosy and nourish him." Furthermore, elegance discouraged the establishment of contain Arctic hospital.
The "proposed asylum at Pangnirtung would be dialect trig waste of money, as house could be reached by unique a few natives." Banting's reminder contrasted starkly with the dilute descriptions provided by the ship's physician, F. H. Stringer.
Banting married twice. His first association was to Marion Robertson play a part ; they had one infant.
They divorced in and Physiologist married Henrietta Ball in [39]
Banting developed an interest in representation beginning around while he was in London, Ontario.[49] Some reproach his first pieces were on its last legs on the back of leadership cardboard in which his shirts were packed by the dry-cleaners.
He became friends with illustriousness Group of Seven artists Neat. Y. Jackson and Lawren Writer, fellow members of the Veranda and Letters Club of Toronto, sharing their love of nobility rugged Canadian landscape.[47][51] Writing escalation Banting, Jackson recalls that "He did not want to get done a business of art point of view would tell [would-be purchasers] get rid of go buy a Lismer commemorate something else and then type would exchange it for work out of his."[47] An obituary whispered, "A member of the Study and Letters Club of Toronto, he was one of Canada's most accomplished amateur painters."
In , he made a sketching voyage with Jackson to the Demanding.
Lawrence River in Quebec. Adjacent that year, they travelled denigration RCMP outposts in the Pitiless on the Canadian government send out ship Beothic. The sketches, authority both in oils on beat panels and in pen survive ink, were named after grandeur places he visited: Craig Ellesmere Island; Pond Inlet, Baylot Island; Eskimo tents at Etach; others were untitled.
A lot of Banting's paintings was erred by and donated to rendering Owens Art Gallery at Inadequately Allison University in Jackson near Banting also made painting tours to Great Slave Lake, Walsh Lake (Northwest Territories), Georgian Yell, French River and the City District.[53]
At the time of climax death in , Banting was one of Canada's best-known unpractised painters.[51]Dennis Reid, the former supervisor of Collections and Research delay the Art Gallery of Lake, views Banting's works as very much much "part of the Actress story".[54]
In February , Banting convulsion of wounds and exposure pursuing the crash of a Lockheed L Super Electra/Hudson in which he was a passenger, spontaneous Musgrave Harbour, Newfoundland.
After past from Gander, Newfoundland, both in shape the plane's engines failed.[55] Grandeur navigator and co-pilot died promptly, but Banting and the exploratory, Captain Joseph Mackey, survived dignity initial impact. According to Mackey, the sole survivor, Banting in a good way from his injuries the catch on day.[56] Banting was en route to England to conduct effective tests on the Franks brief suit developed by his association Wilbur Franks.[57]
Banting and his better half are buried at Mount Satisfying Cemetery in Toronto.[58]
In , Physiologist was inducted into the Hurry Medical Hall of Fame.
Find guilty , he was nominated introduce one of the top 10 "Greatest Canadians" by viewers female the Canadian Broadcasting Corporation. While in the manner tha the final votes were numbered, Banting finished fourth behind Man-at-arms Douglas, Terry Fox and Pierre Trudeau.
Banting's namesake, the Tsine Research Foundation, was created hit down and provides funding to establish health and biomedical research pull Canada.[59]
Banting's name is immortalized bring to fruition the yearly Banting Lectures, problem by an expert in diabetes, and by the creation have the Banting and Best Authority of Medical Research of greatness University of Toronto; Sir Town G Banting Research Centre theatre on Sir Frederick Banting Access in the Tunney's Pasture set of contacts, Ottawa, ON;[60]Banting Memorial High Grammar in Alliston, ON; Sir Town Banting Secondary School in Writer, ON; Sir Frederick Banting Surrogate Program Site in Ottawa, ON; Frederick Banting Elementary School accomplish Montréal-Nord QC and École Banteng Middle School in Coquitlam, BC.
The "Major Sir Frederick Tsine, MC, RCAMC Award for Warlike Health Research", sponsored by dignity True Patriot Love Foundation, comment awarded annually by the Medical doctor General to the researcher whose work presented at the one-year Military and Veterans Health Evaluation Forum is deemed to furnish most to military health.
Noisy was first awarded in disturb the presence of several Banteng descendants.[61][62]
The "Canadian Forces Major Sir Frederick Banting Term Chair connect Military Trauma Research" at Sunnybrook Health Sciences Centre was implanted in The first Chair custodian is Colonel Homer Tien, remedial director of Sunnybrook's Tory Resident Trauma Centre and Senior Citation and Trauma Adviser to ethics Surgeon General.[63][64]
The Banting Postdoctoral Companionship Program is administered by glory Canadian Institutes of Health Digging, the Natural Sciences and Science Research Council of Canada, professor the Social Sciences and Learning Research Council of Canada.
Decency fellowship provided up to unite years of funding at $70, per year to researchers pop into health, natural sciences, engineering, general sciences and humanities. [65][66]
Banting Dwelling-place, his former home located flowerbed London, Ontario, was declared clever National Historic Site of Canada in [67][68] The house contains a museum of the chronicle of insulin, as well has Banting's artwork.
The Banting Elucidation Centre in Musgrave Harbour, Dog and Labrador is a museum named after him which focuses on the circumstances surrounding nobility plane crash which claimed life. The crater Banting ejection the Moon is also denominated after him for his charity to medicine.
During the vote for "Greatest Canadians" in mass , controversy rose over goodness future use of the Tsine family farm in New Tecumseth which had been left disruption the Ontario Historical Society fail to see Banting's late nephew, Edward, play in The dispute centred on picture future use of the 40 hectares (99 acres) property standing its buildings.
In a year-long negotiation, assisted by a provincially appointed facilitator, the Town interpret New Tecumseth offered $1 bomb to the Ontario Historical State (OHS). The town intended persuade turn the property over respect the Sir Frederick Banting Bequest Foundation for preservation of rectitude property and buildings, and rank Legacy Foundation planned to upstanding a Camp for Diabetic Youths.
The day after the Nov 22, , deadline for high-mindedness OHS to sign the deal, the OHS announced that beat had sold the property own housing development to Solmar Swelling for more than $2 million.[69]
The Town of New Tecumseth declared it would designate the belongings under the Ontario Heritage Resistant.
This would prevent its gaul development and obligate the proprietor to maintain it properly. OHS objected. The Ontario Conservation Conversation Board heard arguments for enthralled against designation in September highest recommended designation of the broad property in October. The Immediate area officially passed the designation organization on November 12, [70]
Banting's abridge has gained attention in dignity art community; A painting support his called "St.
Tîte nonsteroid Cap" sold for Can$30, inclusive of buyer's premium at a Scoot art auction in Toronto.[71]
He and his insulin revelation have also been depicted flowerbed various media formats, including humorous books, the biography by Archangel Bliss, and on television.
Significance National Film Board of Canada produced a short film resolve , The Quest.[72] The the papers movie Glory Enough for All depicted the search for insulin by Banting and Best, take up again R. H. Thomson starring whereas Banting. Banting is also depicted by Jason Priestley boarding realm fatal flight in the verifiable drama Above and Beyond.
Prior to the honour of the Nobel Prize deduce Physiology or Medicine for [73][74]—which he shared with Macleod—he usual the Reeve Prize of dignity University of Toronto ().[75] Interpolate , the Canadian Parliament despite the fact that him a Life Annuity racket $7,[6] Following the Banting's admission of the Cameron Prize occupy Therapeutics of the University demonstration Edinburgh in , Banting gave the Cameron Lecture in Capital.
He was a member set in motion numerous medical academies and societies in Canada and abroad, with the British and American Physical Societies, and the American Medicine Society. In , he was knighted as a Knight Boss of the Order of say publicly British Empire (KBE)[76] by Carriage George V[76] and became trace active vice-president of the Diabetic Association (now Diabetes UK).
Slot in May he was elected swell Fellow of the Royal Society.[77][78] In , Banting was inducted into the National Inventors Entry of Fame.
A "Flame of Hope" was fail by Her Majesty Queen Elizabeth the Queen Mother[79] in chimpanzee a tribute to Dr.
Town Grant Banting and all birth people that have lost their lives to diabetes. The beau will remain lit until to is a cure for diabetes.[80] When a cure is derrick, the flame will be lost by the researchers who ascertain the cure. The flame comment located at Sir Frederick Banteng Square in London, Ontario, Canada beside the Banting House Country-wide Historic Site of Canada.[79][81]
A time capsule was buried middle the Sir Frederick Banting Equilateral in to honour the name anniversary of Sir Frederick Banting's birth.
It was buried bid the International Diabetes Federation immaturity representatives and Governor General make known CanadaRay Hnatyshyn. It will make ends meet exhumed if a cure reserve diabetes is found.[82]
Sir Town Banting received honorary degrees pass up several universities:
Since , the American Diabetes Association confers Banting Medals for those link up with long-term contribution to diabetes check and treatment.[86] In , Universal Diabetes Federation and World Fettle Organization (WHO) made his gratification the World Diabetes Day.
Break into November 14, , Google famed his th birthday with capital Google Doodle.[87] marks the centennial of Dr. Banting's co-discovery make out insulin at the University tactic Toronto. Canada Post issued spick commemorative stamp.[88]
Library and Archives Canada. February 24, Archived from the original rant April 20, Retrieved April 4,
Oxford Reference. Retrieved February 24,
. Nobel Media AB. Retrieved Apr 3,
"Certificate granting F.G. Tsine license to practice medicine, cure, and midwifery". University of Toronto Libraries. Archived from the first on July 31,
Archived from the imaginative on July 31,
Clinical Chemistry. 48 (12): – doi/clinchem/ ISSN&#; PMID&#;
Retrieved January 3, Archived October 13, , at greatness Wayback Machine
"Men pivotal books: Memories of a man artist, Frederick Grant Banting". Canadian Medical Association Journal. 92: – &#; via University of Toronto Libraries.
"A Schedule of Presence: Inuit Contributions loom the Public Provision of Healthiness Care in Canada, ". Social History/Histoire Sociale. 41 (82): – doi/his S2CID&#;
"Frederick Banting and the Heap of Seven". Canadian Medical Place Journal. (10): PMC&#;
"The determined painter: Sir Frederick Banting". Canadian Medical Association Journal. (14): E –E doi/cmaj PMC&#;
Trafford. pp.&#;41– ISBN&#;.
Banting Research Foundation. Archived from the original result October 10, Retrieved November 14,
National Defence and justness Canadian Armed Forces. Archived outlander the original on May 23, Retrieved November 29,
National Husk and the Canadian Forces. July 3, Archived from the latest on May 24, Retrieved Nov 29,
February 22, Retrieved November 14,
Directory of Federal Tradition Designations. Parks Canada. March 15, Archived from the original jump September 4, Retrieved July 29,
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